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Alternatively, T can be elevated by the more risky use of anabolic steroids (AAS) or testosterone replacement therapy (TRT)to increase muscle mass without producing adverse effects. Furthermore, the effects of T on muscle growth are often reversible after the patient completes T therapy. The use of T therapy in obesity is controversial. Some argue for its use because of the positive effect it can have on cardiovascular health. Conversely, others argue for the safety of the use of T in obese individuals. T may be beneficial in the prevention of several types of cardiovascular disease, including hypertension, myocardial infarction, stroke, and cardiovascular mortality. There is no consensus on the treatment of obesity to treat anabolic problems. Many studies on T therapy in obese individuals fail to show any significant benefits on measures of obesity-related metabolic outcomes.[5–8] A few studies on the use of T as a treatment for chronic or severe obesity have been conducted. This study reviewed 12 randomized controlled trials involving 462 patients with BMI > 30 kg/m2 or a body mass index of > 30 in overweight or obese adults aged 18–74 years. The investigators concluded that there is insufficient evidence to suggest that weight reduction as a treatment for obesity is beneficial. The results of some studies may be confusing because many of those randomized to T experienced unfavorable weight reduction outcomes and those with a favorable impact of treatment experienced adverse outcomes. Nevertheless, the authors concluded that the magnitude of weight loss from the randomized treatment regimen was modest and not superior to lifestyle approaches in weight loss maintenance. The authors argued that the results from the randomized controlled trials were limited because those who were enrolled and randomized to T experienced adverse events such as hyperglycemia, cardiovascular disease, and elevated lipid levels despite similar weight changes. Another prospective study involving an intervention of 24 obese patients aged 19–84 years that was conducted to determine the safety and efficacy of a combination of lifestyle modification and the use of T for six months showed that T and lifestyle had similar effects on weight and blood pressure as well as body composition. All of the study subjects were randomized to receive T for seven months or lifestyle intervention for five months. Although a small sample size of the randomized controlled trials was present, both the results indicate that the use of T to treat obesity with or without other dietary and/or lifestyle interventions is not warranted. There is no evidence that either lifestyle intervention has any greater effect on weight reduction than the use of a combination of T and diet or that it is beneficial in preventing the development of cardiovascular disease. In addition, evidence suggests that T has a potential to Similar articles: